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kramper. Desuden kan der opstå en stærk trang til atter at indtage stoffet. Ved ophør af behandlingen skal dosis derfor nedtrappes gradvist for at undgå abstinenser. Der kan opstå tolerans ved brug over længere tid. Det betyder, at person har behov for højere og højere doser for at behandle de samme smerter. Der findes forskellige typer af
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